The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...