When axons in the brain and spinal cord of a mammal such as a mouse or a human have been damaged, they don't regenerate on their own. (The only known exception is olfactory sensory nerve cells.) The ...

The capacity of the human central nervous system to regenerate after injury or illness is limited, and the resulting functional impairments carry a vast societal and personal burden. In glaucoma, ...

Top row: Cross-sections through the mouse retina show very little free zinc (Zn2+) in normal mice (purple staining, left panel), but high levels after the optic nerve is injured (right panel). Within ...

A form of gene therapy administered to mice has been shown to protect optic nerve cells and help prevent vision loss or blindness from optic nerve damage and other serious retinal injury, and from ...

A retrospective cohort study found that rapid thinning of the ganglion cell complex was associated with central visual field decline. Faster rates of central visual field (VF) decline were found to be ...

Because the adult mammalian central nervous system has only limited intrinsic capacity to regenerate connections after injury, due to factors both intrinsic and extrinsic to the mature neuron, ...

Many thousands of retinal ganglion cells (RGCs) have to relay signals through the eye's optic nerve via delicate projections, or axons, to precise locations on both sides of the brain that make visual ...

This story is part of a series on the current progression in Regenerative Medicine. This piece is part of a series dedicated to the eye and improvements in restoring vision. In 1999, I defined ...