Nature

Evidence-based interpretation of liver biopsies

‘Evidence based medicine’ is a paradigm introduced in the 1990s in which collection of clinical data in a reproducible and unbiased way is intended to guide clinical decision-making. This paradigm has ...

Experts call meaning, purpose, and spirituality foundational to evidence-based, whole-person lifestyle change

A new peer-reviewed paper calls for meaning, purpose, and spirituality to be treated as core components of lifestyle medicine ...
ascopubs.org

Weighing the Evidence: Variant Classification and Interpretation in Precision Oncology, US Food and Drug Administration Public Workshop—Workshop Proceedings

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma As precision medicine ...
JD Supra

A Guide to FDA’s Evolving Interpretation of How Sponsors Can Demonstrate Substantial Evidence of Effectiveness for Human Drug and Biological Products

A new drug’s effectiveness must be established by “substantial evidence,” which is defined in 505(d) of the Federal Food, Drug, and Cosmetic Act (FDCA). FDA has interpreted the law as generally ...
Psychology Today

On the Hermeneutics of Evidence

[D]ata come to us encrypted, and to understand their meaning we must first break the code --Schmidt 1992, 1170 A serious attempt to answer the vague question posed by Schmidt (1992) of "What Do Data ...
ascopubs.org

Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing

Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non–Small-Cell Lung Cancer Advances in next-generation sequencing technology have led to the ...