A team of researchers unveils a novel, key aspect of enhancer-mediated regulation of gene expression and proposes a mechanism that explains the tight connection between gene enhancers and promoters.

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is an urgent need for effective and targeted therapies that can improve ...

Evgeny Kvon, a geneticist at the University of California, Irvine, fell in love with molecular biology when he learned about the experiments that led to the discovery of DNA as the carrier of genetic ...

(A) Overview of the cohort, including all de novo acute megakaryoblastic leukemia subtypes (n = 75), compared with mononuclear cells derived from the bone marrow (BM) of non-cancer donors under 18 ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Bioengineers used deactivated Cas9 fusion proteins to synthetically control gene expression and reveal new details about natural processes in human cells. Rice University researchers have demonstrated ...

Rice University researchers have demonstrated that CRISPR-Cas9, increasingly famous as a gene-editing tool, can be employed in powerful additional ways in human cells. A team led by Rice bioengineer ...

The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

Your skin cells are clearly different from your brain cells even though they both develop in the same person and carry the same genes. They are different because each cell type expresses a particular ...