Cross-linking mass spectrometry (CLMS) has emerged as a pivotal technique in the investigation of protein interactions and structural organisation. By covalently linking proximal amino acid residues, ...
Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...
Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...
This hands-on course teaches step-by-step techniques for interpreting mass spectrometric data to identify molecular structures. Participants will learn elemental composition analysis, tandem MS ...
Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...
To identify specific chemicals or molecules in the life sciences and medical research, scientists often use mass spectrometry (MS), usually paired with liquid chromatography (LC). These technologies ...
AZoLifeSciences on MSN
Proteomics approaches to overcome undruggable targets in disease
This proteomics-driven approach to drug discovery improves target validation and uncovers insights into undruggable proteins, ...
In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...
The conversion of large-scale, complex mass spectrometry data into meaningful structural insights through ChemEcho, a machine learning embedding method, published in August by investigators at ...
The proteomics market is experiencing strong growth as demand rises for advanced tools that analyze protein structure, ...
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