Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key pathways that regulate tissue homeostasis, inflammation, and several common diseases …

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5][6][7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that targets other proteins …

Jul 21, 2025 · Scientists measure p62 levels to assess autophagic flux, which is the overall rate of degradation. The relationship is inverse: when autophagy runs efficiently, p62 is continuously broken …

Jan 5, 2026 · Using human cells, we found that p62 bodies formed within 1 minute of hyperosmotic stress, and increased with stress severity. They formed faster and under milder stress than stress …

Feb 25, 2025 · This review summarizes and discusses the molecular mechanisms of p62 phase separation and its roles in autophagy, with particular emphasis on the regulation of p62 droplets and …

In the realm of molecular biology, understanding proteins like p62 can shed light on many critical cellular processes. P62, also known as Sequestosome 1, plays a crucial role in autophagy, a cellular …

Oct 14, 2024 · Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and cell viability. The review summarizes the molecular …

Jun 22, 2021 · This review aims to summarize knowledge about the molecular mechanisms underlying the roles of p62 in health and disease. In particular, different types of tumors are characterized by …

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope.

In this review, we highlight recent advances in understanding the role of p62 in coordinating the ubiquitin-proteasome system and autophagy. We also discuss positive and negative effects of p62 …